The potentiation of the anti akinetic effect after L-Dopa treatment by an inhibitor of Mao-B, deprenil
Identifieur interne : 002C56 ( Main/Exploration ); précédent : 002C55; suivant : 002C57The potentiation of the anti akinetic effect after L-Dopa treatment by an inhibitor of Mao-B, deprenil
Auteurs : W. Birkmayer [Autriche] ; P. Riederer [Autriche] ; H. Youdim [Autriche] ; W. Linauer [Autriche]Source :
- Journal of Neural Transmission [ 0300-9564 ] ; 1975-09-01.
Abstract
Summary: The potentiation of the ami akinetic effect after L-Dopa treatment by an inhibitor of monoamine oxidase (MAO) “B”, Deprenil, has been demonstrated in parkinsonian patients with or without previous L-Dopa therapy. Application of the drug has been performed orally, intravenously and intramuscularly. Excellent kinetic effects resulted when combined with Madopar. The combined treatment with L-Dopa was highly effective when applicated i.v. or i.m. Deprenil is an inhibitor of MAO-B and is characterized by less frequent side effects. These are predominantly involuntary movements and confusion, which can be eliminated by lowering the dosage of Deprenil. A daily rhythm of MAO could be demonstrated in several areas of human brains as well in a control group as in parkinsonian patients with or without L-Dopa therapy. Maximal activity of MAO occurs between noon and 6 p.m. The clinical and biochemical data are discussed regarding the off-phenomenons as Deprenil is an excellent drug for preventing these.
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DOI: 10.1007/BF01253131
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Linauer</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:8A8E8BAC0EEF481EE5435F92234EB5AEB2D7B0F2</idno><date when="1975" year="1975">1975</date><idno type="doi">10.1007/BF01253131</idno><idno type="url">https://api.istex.fr/document/8A8E8BAC0EEF481EE5435F92234EB5AEB2D7B0F2/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">002B41</idno><idno type="wicri:Area/Main/Curation">002776</idno><idno type="wicri:Area/Main/Exploration">002C56</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">The potentiation of the anti akinetic effect after L-Dopa treatment by an inhibitor of Mao-B, deprenil</title><author><name sortKey="Birkmayer, W" sort="Birkmayer, W" uniqKey="Birkmayer W" first="W." last="Birkmayer">W. Birkmayer</name><affiliation wicri:level="1"><country xml:lang="fr">Autriche</country><wicri:regionArea>Ludwig-Boltzmann-Institut für Neurochemie, Geriatrisches Krankenhaus der Stadt Wien-Lainz</wicri:regionArea><wicri:noRegion>Geriatrisches Krankenhaus der Stadt Wien-Lainz</wicri:noRegion></affiliation></author><author><name sortKey="Riederer, P" sort="Riederer, P" uniqKey="Riederer P" first="P." last="Riederer">P. Riederer</name><affiliation wicri:level="1"><country xml:lang="fr">Autriche</country><wicri:regionArea>Ludwig-Boltzmann-Institut für Neurochemie, Geriatrisches Krankenhaus der Stadt Wien-Lainz</wicri:regionArea><wicri:noRegion>Geriatrisches Krankenhaus der Stadt Wien-Lainz</wicri:noRegion></affiliation></author><author><name sortKey="Youdim, H" sort="Youdim, H" uniqKey="Youdim H" first="H." last="Youdim">H. 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Neural Transmission</title><idno type="ISSN">0300-9564</idno><idno type="eISSN">1435-1463</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Vienna</pubPlace><date type="published" when="1975-09-01">1975-09-01</date><biblScope unit="volume">36</biblScope><biblScope unit="issue">3-4</biblScope><biblScope unit="page" from="303">303</biblScope><biblScope unit="page" to="326">326</biblScope></imprint><idno type="ISSN">0300-9564</idno></series><idno type="istex">8A8E8BAC0EEF481EE5435F92234EB5AEB2D7B0F2</idno><idno type="DOI">10.1007/BF01253131</idno><idno type="ArticleID">Art10</idno><idno type="ArticleID">BF01253131</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0300-9564</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Summary: The potentiation of the ami akinetic effect after L-Dopa treatment by an inhibitor of monoamine oxidase (MAO) “B”, Deprenil, has been demonstrated in parkinsonian patients with or without previous L-Dopa therapy. Application of the drug has been performed orally, intravenously and intramuscularly. Excellent kinetic effects resulted when combined with Madopar. The combined treatment with L-Dopa was highly effective when applicated i.v. or i.m. Deprenil is an inhibitor of MAO-B and is characterized by less frequent side effects. These are predominantly involuntary movements and confusion, which can be eliminated by lowering the dosage of Deprenil. A daily rhythm of MAO could be demonstrated in several areas of human brains as well in a control group as in parkinsonian patients with or without L-Dopa therapy. Maximal activity of MAO occurs between noon and 6 p.m. The clinical and biochemical data are discussed regarding the off-phenomenons as Deprenil is an excellent drug for preventing these.</div></front></TEI><affiliations><list><country><li>Autriche</li></country></list><tree><country name="Autriche"><noRegion><name sortKey="Birkmayer, W" sort="Birkmayer, W" uniqKey="Birkmayer W" first="W." last="Birkmayer">W. Birkmayer</name></noRegion><name sortKey="Linauer, W" sort="Linauer, W" uniqKey="Linauer W" first="W." last="Linauer">W. Linauer</name><name sortKey="Riederer, P" sort="Riederer, P" uniqKey="Riederer P" first="P." last="Riederer">P. Riederer</name><name sortKey="Youdim, H" sort="Youdim, H" uniqKey="Youdim H" first="H." last="Youdim">H. Youdim</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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